Bone Mineral Disease After Kidney Transplantation
نویسندگان
چکیده
Chronic kidney disease-mineral bone disorder (CKD-MBD) after transplantation is a mix of pre-existing disorders and new alterations. The final consequences are reflected fundamentally as abnormal mineral metabolism (hypercalcemia, hypophosphatemia) alterations [high or low turnover disease (as fibrous osteitis adynamic disease), an eventual compromise mineralization, decrease density fractures]. major cause post-transplantation hypercalcemia the persistence severe secondary hyperparathyroidism, treatment options include calcimimetics parathyroidectomy. On turn, hypophosphatemia caused by both high blood levels PTH and/or FGF23, with its correction being very difficult to achieve. most frequent morphology alteration disease, while high-turnover osteopathy decreases in frequency transplantation. Although pathogenic mechanisms these abnormalities have not been fully clarified, available evidence suggests that there number factors play important role, such immunosuppressive treatment, persistently PTH, vitamin D deficiency hypophosphatemia. Fracture risk four-fold higher transplanted patients compared general population. relevant for fracture transplant population diabetes mellitus, female sex, advanced age (especially > 65 years), dialysis vintage, phosphate levels, osteoporosis, pre-transplant stress doses prolonged steroids therapy. Treatment alternatives CKD-MBD minimization corticosteroids, use calcium supplements, antiresorptives (bisphosphonates Denosumab) osteoformers (synthetic parathyroid hormone). As lead increased morbidity mortality, presence changes has be prevented (if possible), minimized, diagnosed, treated soon possible.
منابع مشابه
Individualized therapy to prevent bone mineral density loss after kidney and kidney-pancreas transplantation.
BACKGROUND AND OBJECTIVES Most patients who undergo kidney or kidney-pancreas transplantation have renal osteodystrophy, and immediately after transplantation bone mineral density (BMD) commonly falls. Together, these abnormalities predispose to an increased fracture incidence. Bisphosphonate or calcitriol therapy can preserve BMD after transplantation, but although bisphosphonates may be more ...
متن کاملDeterminants of reduced bone mineral density and increased bone turnover after kidney transplantation: cross-sectional study.
AIM To analyze bone metabolism and the risk factors of bone loss in kidney transplant recipients. METHODS The bone mineral density (BMD) of the lumbar spine, femoral neck, and radius was determined by dual-energy X-ray absorptiometry in 52 patients 8 days to 228 months after kidney transplantation. Total and bone alkaline phosphatase (BAP), osteocalcin, procollagen, type I collagen telopeptid...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Calcified Tissue International
سال: 2021
ISSN: ['1432-0827', '0171-967X']
DOI: https://doi.org/10.1007/s00223-021-00837-0